N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide ester → 7-[2-(Tert-butoxycarbonylamino)acetyl]amino-2,3-dihydro-1h-imidazo[1,2-b]pyrazole

To a solution of 7-amino-2,3-dihydro-1H-imidazo[1,2-b]pyrazole sulfuric acid salt (1.42 g) and N-ethyldiisopropylamine (2.73 g) in methylene chloride (50 ml) was added N-[2-(tert-butoxycarbonylamino)acetoxy]succinimide (1.90 g). The mixture was stirred at room temperature for 22 hours. The reaction mixture was washed with saturated aqueous sodium hydrogen carbonate solution, and the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The oily residue was purified by column chromatography on silica gel eluting with 5% methanol/chloroform to give 7-[2-(tert-butoxycarbonylamino)acetyl]amino-2,3-dihydro-1H-imidazo[1,2-b]pyrazole (1.07 g) as a solid.

1. washThe reaction mixture was washed with saturated aqueous sodium hydrogen carbonate solution
2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe oily residue was purified by column chromatography on silica gel eluting with 5% methanol/chloroform

ORD 기록

ord-40184e3c41ff4f22818621079f21b59d

출처 데이터셋

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07129232B2