Hydrochloric Acid → 1H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)

HRID 1247843노트

반응식

HRID 1247843 반응식
[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH:9]C=O)=[CH:7][CH:6]=[N:5]1.Cl>CO>[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[CH:7][CH:6]=[N:5]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 85666041HCID 85666041, 화합물

생성물 1

HCID 219045531H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of [1-(2-fluoroethyl)-1H-pyrazol-5-yl]formamide (15.7 g) in methanol (78 ml) was added concentrated hydrochloric acid (21 ml) at room temperature. The reaction mixture was stirred for 3.5 hours and evaporated in vacuo. The residue was dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate solution. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give 1-(2-fluoroethyl)-1H-pyrazol-5-amine (12 g).

후처리

  1. customevaporated in vacuo
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with aqueous sodium hydrogen carbonate solution
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e8f5b1f3ed5345d3b0d33a8807d2cb7d
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129232B2

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