Diisopropyl Ether → HCID 21904559, 화합물

HRID 1247844노트

반응식

HRID 1247844 반응식
[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[CH:7][CH:6]=[N:5]1.[N:10](OCCC(C)C)=[O:11].C(OC(C)C)(C)C.CCCCCC>C(O)C.Cl>[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[C:7]([N:10]=[O:11])[CH:6]=[N:5]1

참가 물질

7

반응물 4

HCID 7914Diisopropyl EtherHCID 8053Isoamyl NitriteHCID 8058HexaneHCID 219045531H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)

생성물 1

HCID 21904559HCID 21904559, 화합물수율 32.7%

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 702Ethanol용매

실험 절차

To a solution of 1-(2-fluoroethyl)-1H-pyrazol-5-amine (12 g) in ethanol (30 ml) were added concentrated hydrochloric acid (70 mg) and isoamyl nitrite (10.9 g). The reaction mixture was stirred at 25–38° C. for 2 hours. Diisopropyl ether and hexane were added to the reaction mixture, and the resulting oil was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2→1:1→2:1→1:0) to give-1-(2-fluoroethyl)-4-nitroso-1H-pyrazol-5-amine (4.8 g).

후처리

  1. customthe resulting oil was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2→1:1→2:1→1:0)

출처 및 근거

ORD 기록
ord-fbe02c8ba7854209942fbdce6ecabe21
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129232B2

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