Ethylenediamine → 6-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1247887노트

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[Br:16].CS[N:19]=[C:20]=O.[CH2:22](N)[CH2:23][NH2:24]>>[Br:16][C:3]1[CH:4]=[C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)[CH:6]=[CH:7][C:2]=1[NH:1][C:20]1[NH:19][CH2:22][CH2:23][N:24]=1

참가 물질

반응물 3

HCID 3301Ethylenediamine

HCID 202792156-(4-Amino-3-bromophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

HCID 21933440Methylthioisocyanate

생성물 1

HCID 132173476-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

실험 절차

Using 6-(4-amino-3-bromophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and methylthioisocyanate, the reaction was carried out in the same manner as described in Example 1(b) to the corresponding methylisothiuronium salt which was then reacted with ethylenediamine in the same manner as described in Example 1(c) to afford the above-identified compound. M.P. 265°-267° C. (with decomp.).

후처리

customto afford the above-identified compound

출처 및 근거

ORD 기록: ord-7edb9ac9cca4413199e59b4400518b73
출처 데이터셋: uspto-grants-1985_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04521415

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