Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(2-Naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(2-Naphthyl)acetyl chloride | HCID 588115 | — |
| 반응물 | 4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine | HCID 11128034 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(2-Naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine | HCID 13277374 | 75.7% |
반응 단계
By operating as described in Example 6(a), 7 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine are reacted with 6.15 g of 2-naphthylacetyl chloride in the presence of 4.15 g of triethylamine in methylene chloride to give 9 g of 1-(2-naphthylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; m.p. 125°-130° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04521428 |
| 출처 데이터셋 | uspto-grants-1985_06 |
| ORD ID | ord-47ed5670983843d5937ff17dc215f293 |
| 출처 메모 | uspto-grants-1985_06 |