Sodium Hydroxide → 3-Carbamoyl-2,4,6-triiodophenoxyacetic acid
반응식
[C:1]([C:3]1[C:4]([I:16])=[C:5]([C:11]([I:15])=[CH:12][C:13]=1[I:14])[O:6][CH2:7][C:8]([OH:10])=[O:9])#[N:2].[OH-:17].[Na+]>>[C:1]([C:3]1[C:4]([I:16])=[C:5]([C:11]([I:15])=[CH:12][C:13]=1[I:14])[O:6][CH2:7][C:8]([OH:10])=[O:9])(=[O:17])[NH2:2]참가 물질
3
실험 절차
27.3 g (49 mmol) of 3-cyano-2,4,6-triiodophenoxyacetic acid is stirred in 100 of 2N sodium hydroxide solution for 3 hours at 50° C. The resultant alkaline solution is filtered over active carbon for purifying and decolorizing and then brought to pH 2 by adding 2N hydrochloric acid. After several hours of stirring in an ice bath, the yield is 23.9 g (85% of theory) of 3-carbamoyl-2,4,6-triiodophenoxyacetic acid as a white powder, mp 211°-213° C. (decomposition).
후처리
- filtrationThe resultant alkaline solution is filtered over active carbon
- customfor purifying
- additionby adding 2N hydrochloric acid
출처 및 근거
- ORD 기록
- ord-0eb2d21599ea4a7ebee922bc67a9326f
- 출처 데이터셋
- uspto-grants-1985_06
- 특허 번호
- US04522839
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