Dimethylformamide → N-[3-(6-Piperidinomethyl-2-pyridyloxy)propyl]formamide

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[H-].[Na+].Cl[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[N:10]=1.CN([CH:25]=[O:26])C>>[N:16]1([CH2:15][C:11]2[N:10]=[C:9]([O:5][CH2:4][CH2:3][CH2:2][NH:1][CH:25]=[O:26])[CH:14]=[CH:13][CH:12]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

참가 물질

반응물 4

HCID 6228Dimethylformamide2회

HCID 90863-Amino-1-propanol

HCID 24758Sodium hydride

HCID 133886862-Chloro-6-(piperidin-1-ylmethyl)pyridine

생성물 1

HCID 13491499N-[3-(6-Piperidinomethyl-2-pyridyloxy)propyl]formamide

실험 절차

3-Aminopropanol (12.84 g, 0.171 mole) was added to a suspension of 50% sodium hydride in mineral oil (7.96 g, 0.166 mole) in 180 mL of dry DMF and the mixture was warmed to 80°-83°. A solution of 2-chloro-6-piperidinomethylpyridine (34.0 g, 0.161 mole) [prepared in Step A] in 180 mL of dry DMF was then added dropwise and then complete, the temperature was raised to 125°-128° for 3 hours followed by 17 hours at ambient temperature. The precipitated salts were removed by filtration and the solvent stripped under vacuum. The oily residue was dissolved in methylene chloride, washed with water, dried and the solvent evaporated. This residue was redissolved in acetonitrile and extracted with skelly B. After removing the solvent the crude oil was purified by flash chromatography on 270 g of silica gel (230-400 mesh) using a gradient elution of methanol-methylene chloride and evaporated to give the title product as a yellow oil, 21.63 g (48.4%).