Propargyl bromide → 5-Methyl-2-propargyloxyphenylsulfonamide
반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[C:20]#[CH:21]>C(#N)C>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([O:1][CH2:21][C:20]#[CH:19])=[C:3]([S:9]([NH2:12])(=[O:10])=[O:11])[CH:4]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 24.3 g of 2-hydroxy-5-methylphenylsulfonamide, 36.0 g of potassium carbonate, 16.7 g of propargyl bromide and 500 ml of acetonitrile is stirred at 50° C. for 4.5 hours. The reaction mixture is then filtered, and concentrated by evaporation. The yield after recrystallisation from ethyl acetate is 23.9 g of 5-methyl-2-propargyloxyphenylsulfonamide, m.p. 169°-170° C.
후처리
- filtrationThe reaction mixture is then filtered
- concentrationconcentrated by evaporation
- customThe yield
- customafter recrystallisation from ethyl acetate
출처 및 근거
- ORD 기록
- ord-127d623726274a86a75da5c167078b81
- 출처 데이터셋
- uspto-grants-1985_06
- 특허 번호
- US04523944
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