5-(3-Pyridylmethyl)-4-pyrimidone → 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone

HRID 1248412

반응식

HRID 1248412 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][C:8]1[O:12][C:11]([CH2:13][N:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=1.[N:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][C:24]2[C:25](=[O:30])[NH:26][CH:27]=[N:28][CH:29]=2)[CH:18]=1>>[CH3:15][N:14]([CH2:13][C:11]1[O:12][C:8]([CH2:7][O:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:27]2[NH:26][C:25](=[O:30])[C:24]([CH2:23][C:19]3[CH:18]=[N:17][CH:22]=[CH:21][CH:20]=3)=[CH:29][N:28]=2)=[CH:9][CH:10]=1)[CH3:16]

참가 물질

3

반응물 2

HCID 204481775-(3-Pyridylmethyl)-4-pyrimidoneHCID 212975835-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine

생성물 1

HCID 202778842-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone수율 52.2%

실험 절차

A mixture of 5-[(4-aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine (1 g) and 2-methylthio)-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone (1 g) was heated at 140° for 7 h. Column chromatography (silica/methanol) of the residue yielded the title compound (0.95 g) as a yellow oil.

후처리

  1. temperaturewas heated at 140° for 7 h

출처 및 근거

ORD 기록
ord-0641ff2f19e949608b077180c477192a
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04524071

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