2,2,6,6-Tetramethylpiperidine → HCID 12951849, 화합물

HRID 1248796노트

반응식

HRID 1248796 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH2:7]Br.[CH3:11][NH:12][CH2:13][CH2:14][CH:15]([OH:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CC1(C)CCCC(C)(C)N1>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][N:12]([CH2:13][CH2:14][CH:15]([OH:22])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH3:11])[CH:9]=1

참가 물질

5

반응물 3

HCID 130352,2,6,6-TetramethylpiperidineHCID 27339893-Methylamino-1-phenylpropanolHCID 27736262-(Bromomethyl)-4-chloro-1-fluorobenzene

생성물 1

HCID 12951849HCID 12951849, 화합물수율 73.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

A solution of 5-chloro-2-fluorobenzyl bromide (10.5 g) in acetonitrile (100 ml) was added dropwise to a mixture of N-methyl-3-hydroxy-3-phenylpropylamine (7.7 g), 2,2,6,6-tetramethylpiperidine (8 ml) and acetonitrile (100 ml) After 12 h the mixture was filtered, the filtrate evaporated and the residue chromatographed on silica (Woelm Grade 1) using ether as eluant to give the title compound as an oil (10.5 g), b.p. 160°/0.5 mm.

후처리

  1. filtrationwas filtered
  2. customthe filtrate evaporated
  3. customthe residue chromatographed on silica (Woelm Grade 1)

출처 및 근거

ORD 기록
ord-5af6250c11304b38834468bb30d787f9
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04626522

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