N,N-Dimethylaniline → 1-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

HRID 1248833노트

반응식

HRID 1248833 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:17][CH:16]=2)[C:3]=1[C:4](O)=[O:5].CN(C)C1C=CC=CC=1.P(Cl)(Cl)(Cl)=O>ClCCCl>[Cl:1][C:2]1[C:3]2[C:4](=[O:5])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:19]=3)[NH:14][C:7]=2[C:8]([N+:11]([O-:13])=[O:12])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 13588229HCID 13588229, 화합물

생성물 1

HCID 135883221-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Four grams of 2-chloro-5-nitro-6-[[4-(phenylmethoxy)phenyl]amino]benzoic acid was suspended in 80 ml of boiling 1,2-dichloroethane to which 0.2 ml of N,N-dimethylaniline was added followed by 8.0 ml of phosphorus oxychloride. The mixture was stirred under reflux for 30 minutes and cooled overnight. The resulting suspension was filtered providing the title compound as a red solid, mp 216°-217° C.

후처리

  1. additionwas added
  2. temperatureunder reflux for 30 minutes
  3. temperaturecooled overnight
  4. filtrationThe resulting suspension was filtered

출처 및 근거

ORD 기록
ord-e7d21bc4d78845a6a4ba72571a10a7fd
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04626540

반응 노트

불러오는 중…