Water → 4,6-Dimethyl-2-(4-nitrophenoxy)pyrimidine

HRID 1248893

반응식

HRID 1248893 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[K+].Cl[C:14]1[N:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[N:15]=1.O>CS(C)=O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:14]2[N:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[N:15]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 9804-NitrophenolHCID 14797Potassium HydroxideHCID 205502-Chloro-4,6-dimethylpyrimidine

생성물 1

HCID 7760484,6-Dimethyl-2-(4-nitrophenoxy)pyrimidine수율 77.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

27.8 g (0.2 mole) of 4-nitro-phenol were dissolved in 100 ml of dimethylsulphoxide. After addition of 11.2 g (0.2 mole) of powdered potassium hydroxide, the mixture was stirred at room temperature for 30 minutes and 28.5 g (0.2 mole) of 2-chloro-4,6-dimethyl-pyrimidine were then added. The mixture was heated at 120° C. for 6 hours and then cooled, stirred with one liter of water and filtered off with suction. The crystals filtered off with suction were dried in air. 38 g (77.5% of theory) of 2-(4-nitrophenoxy)-4,6-dimethyl-pyrimidine were obtained.

후처리

  1. temperatureThe mixture was heated at 120° C. for 6 hours
  2. temperaturecooled
  3. filtrationfiltered off with suction
  4. filtrationThe crystals filtered off with suction
  5. customwere dried in air

출처 및 근거

ORD 기록
ord-c5d7b8dc7d31458e971675969b6a5420
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04627871

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