Hydrazine hydrate (1:1) → (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazide

HRID 1249101노트

반응식

HRID 1249101 반응식
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([O:16]CC)=O)[NH:2]1.O.[NH2:20][NH2:21]>CN(C)C=O>[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([NH:20][NH2:21])=[O:16])[NH:2]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 1079579ethyl (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate

생성물 1

HCID 7109654(3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazide수율 74%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of ethyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (4.9 g), hydrazine hydrate (10 ml) and dimethylformamide (50 ml) is allowed to stand at room temperature overnight. The reaction mixture is is distilled under reduced pressure to remove the solvent. The residue is treated with ethyl acetate to give the title compound (3.40 g, 74%) as powder.

후처리

  1. distillationThe reaction mixture is is distilled under reduced pressure
  2. customto remove the solvent
  3. additionThe residue is treated with ethyl acetate

출처 및 근거

ORD 기록
ord-7bb566fabe9947ca831ad8d0c22c6d56
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04628057

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