Sodium Hydroxide → HCID 762190, 화합물

HRID 1249105노트

반응식

HRID 1249105 반응식
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([O:19]C)=[O:18])[NH:5]1)[CH2:2][CH3:3].[OH-].[Na+]>CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86741022HCID 86741022, 화합물

생성물 1

HCID 762190HCID 762190, 화합물수율 81.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl (1RS,3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1.3 g), 1N NaOH (5.5 ml) and methanol (8 ml) is stirred at room temperature for 1.5 hours. The mixture is distilled under reduced pressure to remove methanol. The residue is adjusted to pH 4 with 10% HCl, and the precipitated crystals are collected by filtration, washed with water and then dried to give the title compound (1.0 g, 81%) as colorless needles, m.p. 225°-226° C.

후처리

  1. distillationThe mixture is distilled under reduced pressure
  2. customto remove methanol
  3. filtrationthe precipitated crystals are collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-830b5595f8d946fe892f1e19364044ce
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04628057

반응 노트

불러오는 중…