Trimethylsilyl cyanide → 2-(3-Bromophenyl)-2-methoxyethan-1-amine

HRID 1249208노트

반응식

HRID 1249208 반응식
CO[CH:3]([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1.C[Si]([C:17]#[N:18])(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>[I-].[Zn+2].[I-].C(#N)C>[CH3:12][O:11][CH:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1)[CH2:17][NH2:18]

참가 물질

6

반응물 3

HCID 82115Trimethylsilyl cyanideHCID 1053951-Bromo-3-(dimethoxymethyl)benzeneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 202252042-(3-Bromophenyl)-2-methoxyethan-1-amine

시약·촉매·용매 2

HCID 9883512zinc(II)iodide촉매HCID 6342Acetonitrile용매

실험 절차

1-Methoxy-1-(3-bromophenyl)acetonitrile was prepared from 3-bromobenzaldehyde dimethyl acetal and trimethylsilyl cyanide, using zinc iodide as catalyst, by an analogous procedure to that described in Example X1. Reduction of the acetonitrile with lithium aluminium hydride by an analogous procedure to that described in Example X2 gave the title compound.

출처 및 근거

ORD 기록
ord-9cc7b076408d44caa43e11ed6f07988e
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04629737

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