Hydroxylamine → HCID 13340177, 화합물

HRID 1249629

반응식

HRID 1249629 반응식
[O:1]1[CH2:3][CH:2]1[C:4]1[N:9]=[C:8]2[CH2:10][O:11][CH:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][C:7]2=[CH:6][CH:5]=1.[C:20]([NH:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH3:23])([CH3:22])[CH3:21].OC(C1N=CC=CC=1)CN(CC1C=CC=CC=1)C(C)(C)C.NO>CO>[OH:1][CH:2]([C:4]1[N:9]=[C:8]2[CH2:10][O:11][CH:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][C:7]2=[CH:6][CH:5]=1)[CH2:3][N:24]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]([CH3:23])([CH3:21])[CH3:22]

참가 물질

6

반응물 4

HCID 787HydroxylamineHCID 76908N-(1,1-Dimethylethyl)benzenemethanamineHCID 137484036-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridineHCID 53930912HCID 53930912, 화합물

생성물 1

HCID 13340177HCID 13340177, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 33.0 g. (0.13 mole) 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino-[5,4-b]pyridine and 22.0 g. (0.135 mole) of N-tert-butylbenzylamine in 200 ml. of methanol was heated to the reflux temperature overnight. Upon cooling there deposited 6-[1- hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine which was recrystallized from isopropanol to give 29.4 g. (54%) of the amino alcohol m.p. 126°-130° C.

후처리

  1. customwas recrystallized from isopropanol
  2. customto give 29.4 g

출처 및 근거

ORD 기록
ord-e286de22e5854b9da3b1fae569df5f35
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04632992

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