Sodium Hydroxide → 8-Hydroxyquinoline

HRID 1249644노트

반응식

HRID 1249644 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2S([O-])(=O)=O)[CH:4]=[CH:3][CH:2]=1.[Na+].[OH-:16].[Na+]>O>[OH:16][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:1]=[CH:2][CH:3]=[CH:4]2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 23669146Sodium quinoline-8-sulfonate

생성물 1

HCID 19238-Hydroxyquinoline수율 97.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium quinoline-8-sulfonate (231 g) was added to 170 g of a 50% aqueous solution of sodium hydroxide, and the mixture was stirred. Then, 900 g of a hydrogenated triphenyl mixture was mixed, and the mixture was dehydrated. The dehydrated mixture was reacted at 260° C. for 15 minutes in a nitrogen stream. After cooling, 600 ml of water was added to the reaction mixture to separate the reaction medium layer. The aqueous layer was decolorized with activated carbon, acidified and then extracted with 200 ml of chloroform. The chloroform was recovered to give 140.9 g (yield 97.2%) of 8-hydroxyquinoline.

후처리

  1. customThe dehydrated mixture was reacted at 260° C. for 15 minutes in a nitrogen stream
  2. temperatureAfter cooling
  3. customto separate the reaction medium layer
  4. extractionextracted with 200 ml of chloroform
  5. customThe chloroform was recovered

출처 및 근거

ORD 기록
ord-598777ab442c45c7ac24497548efd2a9
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04633024

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