Hydrochloric Acid → 1-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride

반응식

[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([O:10]CC2C=CC=CC=2)=[C:4]1[CH2:18][O:19]C)[CH3:2].[ClH:21]>>[ClH:21].[CH2:1]([N:3]1[CH:8]=[CH:7][C:6](=[O:9])[C:5]([OH:10])=[C:4]1[CH2:18][OH:19])[CH3:2]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 186788071-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one

생성물 1

HCID 699564981-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride수율 73%

실험 절차

2.0 g (7.33 mmol) 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)one was dissolved in 50 ml of 4N hydrochloric acid and refluxed for 6 hours. Concentration to dryness in vacuo afforded the crude product. Recrystallisation from methanol/diethyl ether gave the pure title compound (1.1 g, 73%) as a white crystalline solid. m.p. 168-169° C.

후처리

temperaturerefluxed for 6 hours
concentrationConcentration to dryness in vacuo
customafforded the crude product
customRecrystallisation from methanol/diethyl ether

출처 및 근거

ORD 기록: ord-aba0a65d3fc641afb41426bd73510522
출처 데이터셋: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06335353B1

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