Sodium Hydroxide → HCID 18329461, 화합물
반응식
[CH:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1[C:12]1[O:13]CC(C)(C)N=1)([CH3:3])[CH3:2].[OH-:19].[Na+]>S(=O)(=O)(O)O>[CH:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:5]=1[C:12]([OH:13])=[O:19])([CH3:2])[CH3:3]참가 물질
4
실험 절차
A solution of 2-(2-isopropyl-3-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole (6.18 g, 25 mmol) in 35% solution of sulfuric acid (40 mL) was stirred at reflux for 48 hours. Upon cooling, solid sodium hydroxide (18.15 g) was slowly added. The reaction mixture was extracted with diethyl ether, and the combined organic extracts were extracted with sodium bicarbonate solution. The bicarbonate extracts were then acidified with 3N hydrochloric acid, filtered and dried to give 2-isopropyl-3-methoxybenzoic acid as a white crystalline solid (1.73 g, 35.7%).
후처리
- temperatureat reflux for 48 hours
- temperatureUpon cooling
- extractionThe reaction mixture was extracted with diethyl ether
- extractionthe combined organic extracts were extracted with sodium bicarbonate solution
- filtrationfiltered
- customdried
출처 및 근거
- ORD 기록
- ord-3ad4948b116840b2937f37c82abe7cd7
- 출처 데이터셋
- uspto-grants-2002_01
- 특허 번호
- US06335459B1
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