Allylamine → 2-Allylamino-4-dodecylamino-6-nitroquinazoline

HRID 1250599

반응식

HRID 1250599 반응식
Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1.[CH2:28]([NH2:31])[CH:29]=[CH2:30]>O>[CH2:28]([NH:31][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1)[CH:29]=[CH2:30]

참가 물질

4

반응물 2

HCID 7853AllylamineHCID 183265162-Chloro-4-dodecylamino-6-nitroquinazoline

생성물 1

HCID 183265482-Allylamino-4-dodecylamino-6-nitroquinazoline수율 93.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 170 mg (0.44 mmol) of 2-chloro-4-dodecylamino-6-nitroquinazoline was added 1.70 ml (22.66 mmol) of allylamine, and then the resulting mixture was stirred at room temperature overnight. After water was added to the reaction solution, crystals thus precipitated were filtered to give 170 mg (93.4%) of the title compound.

후처리

  1. customthus precipitated
  2. filtrationwere filtered

출처 및 근거

ORD 기록
ord-46e3260cc7e241ce9c3303d32471a74b
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

연결된 노트

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