4-Chloro-2-toluidine → N-(4-Chloro-2-methyl-phenyl)-propane-1,3-diamine

HRID 1250874

반응식

HRID 1250874 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.Br.Br[CH2:12][CH2:13][CH2:14][NH2:15].[OH-].[Na+]>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:12][CH2:13][CH2:14][NH2:15])=[C:4]([CH3:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 72514-Chloro-2-toluidineHCID 14798Sodium HydroxideHCID 787013-Bromopropylamine hydrobromide

생성물 1

HCID 18324816N-(4-Chloro-2-methyl-phenyl)-propane-1,3-diamine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-chloro-2-methylaniline (8 g) and 3-bromopropylamine hydrobromide (5 g) was heated at 100° C. for fifteen minutes. After cooling to room temperature, the resulting crystalline solid was dissolved in water (50 mL) and one equivalent of sodium hydroxide was added. This solution was then washed with ethyl ether and basified with excess sodium hydroxide. It was then extracted with dichloromethane, the combined extracts were dried over anhydrous potassium carbonate and evaporated to dryness.

후처리

  1. temperatureAfter cooling to room temperature
  2. washThis solution was then washed with ethyl ether and basified with excess sodium hydroxide
  3. extractionIt was then extracted with dichloromethane
  4. dry with materialthe combined extracts were dried over anhydrous potassium carbonate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d50cdada08774a14b9f3f62287fcc4b9
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06340687B1

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