Sodium Hydroxide → HCID 9856593, 화합물

HRID 1251008노트

반응식

HRID 1251008 반응식
[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([O:19]C)=[O:18].[OH-].[Na+]>C1COCC1>[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([OH:19])=[O:18]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10588717HCID 10588717, 화합물

생성물 1

HCID 9856593HCID 9856593, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic acid, methyl ester (0.80 g, 2.87 mmol) in THF (50 mL) was added aqueous 1.0N NaOH (4.3 mL, 4.3 mmol), and the reaction mixture was refluxed for 23 hours. The product is precipitated upon acidification with conc. HCL and recrystallized from water to give 0.73 g (96%).

후처리

  1. temperaturethe reaction mixture was refluxed for 23 hours
  2. customThe product is precipitated upon acidification with conc. HCL
  3. customrecrystallized from water
  4. customto give 0.73 g (96%)

출처 및 근거

ORD 기록
ord-54e8e249a5524c0ca6c8a7aa9db7991b
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06340758B1

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