Hydrochloric Acid → 4-(1H-pyrazol-3-yl)aniline

HRID 1251467

반응식

HRID 1251467 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.O.O.[Sn](Cl)Cl.Cl>C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[NH:14][N:13]=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 61436Stannous chloride dihydrateHCID 27370713-(4-Nitrophenyl)-1H-pyrazole

생성물 1

HCID 27353994-(1H-pyrazol-3-yl)aniline수율 95.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-(4-nitrophenyl)pyrazole (10.1 g) in ethanol (100 ml) was added Tin(II) chloride dihydrate (35.7 g) and concentrated hydrochloric acid (25.5 ml). After the addition was completed, the reaction mixture was refluxed for 3 hours. After cooling, the solvent was evaporated and strongly basified (NaOH solution) and then extracted with chloroform. The extract was washed with brine, dried (MgSO4) and evaporated to dryness to obtain the title compound (8.1 g).

후처리

  1. additionAfter the addition
  2. temperaturethe reaction mixture was refluxed for 3 hours
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. extractionstrongly basified (NaOH solution) and then extracted with chloroform
  6. washThe extract was washed with brine
  7. dry with materialdried (MgSO4)
  8. customevaporated to dryness

출처 및 근거

ORD 기록
ord-2ee85007c9e44ccab33ddfa300ff1533
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342516B1

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