Methyl vinyl ketone → Piperitenone

HRID 1251626

반응식

HRID 1251626 반응식
[O:1]=[C:2]([CH:4]=[C:5]([CH3:7])[CH3:6])[CH3:3].[C:8](=O)([O-])[O-].[K+].[K+].[CH:14]([C:16](C)=O)=[CH2:15]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[CH3:6][C:5]1[CH2:7][CH2:8][C:3](=[C:14]([CH3:16])[CH3:15])[C:2](=[O:1])[CH:4]=1

참가 물질

5

반응물 3

HCID 6570Methyl vinyl ketoneHCID 8858Mesityl oxideHCID 11430Potassium Carbonate

생성물 1

HCID 381152Piperitenone수율 62%

시약·촉매·용매 1

HCID 66133Benzyl triethylammonium chloride촉매

반응 조건

온도
80 °C

실험 절차

A 688 ml (6.0 mol) portion of mesityl oxide was put into a one liter capacity four neck flask and mixed with 13.82 g (0.1 mol) of potassium carbonate and 2.28 g (10 mmol) of benzyltriethylammonium chloride, and the mixture was heated to 80° C. To this was added dropwise 166.48 ml (2.0 mol) of methyl vinyl ketone spending 1 hour while keeping at 80° C. After completion of the dropwise addition, this was stirred for 30 minutes and then the reaction solution was distilled under a reduced pressure to obtain 186 g of piperitenone. Yield 62%.

후처리

  1. customwhile keeping at 80° C
  2. additionAfter completion of the dropwise addition
  3. distillationthe reaction solution was distilled under a reduced pressure

출처 및 근거

ORD 기록
ord-d2d191a2702e4faa9c85cb404e4a74d9
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342644B1

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