Pulegol → Neoisomenthol

HRID 1251630

반응식

HRID 1251630 반응식
[CH3:1][CH:2]1[CH2:10][CH:9]([OH:11])[C:5](=[C:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1>[Pd].[C].C(OCC)(=O)C>[CH3:1][C@H:2]1[CH2:10][C@@H:9]([OH:11])[C@@H:5]([CH:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 92793Pulegol

생성물 1

HCID 19244Neoisomenthol수율 90%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

반응 조건

온도
60 °C

실험 절차

A 100 ml capacity autoclave was charged with 1.0 g (6.5 mmol) of pulegol, 5% Pd-carbon (20 mg) and ethyl acetate (5 ml), and the mixture was stirred at 60° C. for 5 hours under a hydrogen pressure of 2 Mpa. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated. A 0.99 g portion of a mixture of menthol:neoisomenthol=91:9 was obtained. The yield was 90%.

후처리

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to room temperature
  3. concentrationconcentrated
  4. additionA 0.99 g portion of a mixture of menthol

출처 및 근거

ORD 기록
ord-ee8680ab80ff49fab1bb95cf6419c2a8
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342644B1

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