Sodium Hydroxide → HCID 23499547, 화합물

HRID 1251882노트

반응식

HRID 1251882 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 23499548Methyl 4-methoxy-2-(4-fluorophenyl)benzoate

생성물 1

HCID 23499547HCID 23499547, 화합물수율 107.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 4-methoxy-2-(4-fluorophenyl)benzoate (9.8 g; 0.029 mol) in methanol (75 ml) was added 2N aqueous sodium hydroxide solution (45 ml) and the mixture heated at reflux for 1.5 h. The reaction was cooled to ambient temperature, filtered and the filtrate concentrated in vacuo to remove the methanol. The residual aqueous phase was washed with diethyl ether, acidified to pH 1 with concentrated HCl and extracted with ethyl acetate. The organic extracts were dried (MgSO4) and the solvent removed in vacuo to give 4-methoxy-2-(4-fluorophenyl)benzoic acid as a white solid (7.7 g), which was used without further purification.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 1.5 h
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated in vacuo
  5. customto remove the methanol
  6. washThe residual aqueous phase was washed with diethyl ether
  7. extractionextracted with ethyl acetate
  8. dry with materialThe organic extracts were dried (MgSO4)
  9. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-04662595b38149218818428512bf04e4
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342765B1

반응 노트

불러오는 중…