Sodium Hydroxide → 5-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid

HRID 1251902노트

반응식

HRID 1251902 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)=[C:21]([CH:26]=2)[C:22]([O:24]C)=[O:23])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[C:11]2[CH3:15])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)=[C:21]([CH:26]=2)[C:22]([OH:24])=[O:23])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[C:11]2[CH3:15])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 18324372Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate

생성물 1

HCID 183243915-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid수율 45.2%

실험 절차

Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate (4.2 g, ˜8.8 mmol) was hydrolysed with aqueous sodium hydroxide solution under the usual conditions to give 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid (1.84 g, ˜45% ) as a colourless gum.

출처 및 근거

ORD 기록
ord-d61e547e760746fdb39dd245629a423c
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342765B1

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