Acetone → Ethyl 4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate

HRID 1251952노트

반응식

HRID 1251952 반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14].C([O-])([O-])=O.[K+].[K+].[CH2:24](I)[CH3:25].[CH3:27][C:28](C)=O>>[CH2:27]([O:1][C:2]1[CH:7]=[C:6]([O:8][CH2:24][CH3:25])[N:5]=[C:4]([C:9]([F:12])([F:10])[F:11])[C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:28]

참가 물질

5

반응물 4

HCID 180AcetoneHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 178470040HCID 178470040, 화합물

생성물 1

HCID 13726789Ethyl 4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate수율 82.9%

실험 절차

This material was prepared in 82.9% yield from product of Example 1 (1 eq), K2CO3 (2 eq) and excess ethyl iodide. The reaction mixture was refluxed in acetone for 18 hours and filtered. The filtrate was concentrated. The residue was dissolved in ether. The ether solution was washed with 10% K2CO3, dried (MgSO4) and concentrated to give the product as an oil, nD25 1.4534.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. dissolutionThe residue was dissolved in ether
  4. washThe ether solution was washed with 10% K2CO3
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-efe1bed73b714a7e80930fbb3e47aa1b
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04741766

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