Sodium Hydroxide → 4-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazole

HRID 1252079노트

반응식

HRID 1252079 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][O:25]C(=O)C)[S:20][CH:21]=3)[CH2:12][CH2:11]2)=[CH:2]1.[OH-].[Na+]>C(O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][OH:25])[S:20][CH:21]=3)[CH2:14][CH2:15]2)=[CH:2]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 141297994-[4-(3-Indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole

생성물 1

HCID 141298054-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazole수율 34.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 4-[4-(3-indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole (0.9 g) in ethanol (20 ml) was added 1N aqueous solution of sodium hydroxide (3 ml). After one hour of stirring, the reaction mixture was concentrated and the resulting precipitate was collected by filtration and recrystallized from a mixture of water and ethanol to give 4-[4-(3-indolyl)piperidinomethyl]-2-glycoloylaminothiazole (0.28 g).

후처리

  1. concentrationthe reaction mixture was concentrated
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from a mixture of water and ethanol

출처 및 근거

ORD 기록
ord-f8b177ca19dd43c4bacff1b125b8ecc9
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04742057

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