Ethanol → Sbb043676
반응식
C(O)C.[NH2:4][C:5]1[S:6][C:7]([SH:10])=[N:8][N:9]=1.[OH-].[Na+].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>O>[NH2:4][C:5]1[S:6][C:7]([S:10][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[N:8][N:9]=1참가 물질
6
실험 절차
To 190 ml of ethanol and 240 ml of water, 81.5 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 26.9 g of sodium hydroxide were added. To this mixture 99.0 g of 1-bromohexane was added and the resulting mixture was stirred at 60°-70° C. for 2 hours. After cooling, water was added to the mixture and the mixture was filtered. The residue was washed with water, dried under reduced pressure, and recrystallized from an ethanol/hexane mixture. Thus 100.5 g of 2-amino-5-hexylthio-1,3,4-thiadiazole was obtained. m.p. 113°-115° C. Yield 77%.
후처리
- temperatureAfter cooling
- filtrationthe mixture was filtered
- washThe residue was washed with water
- customdried under reduced pressure
- customrecrystallized from an ethanol/hexane mixture
출처 및 근거
- ORD 기록
- ord-5c2db0debd1f48c0a317cc74015b94a9
- 출처 데이터셋
- uspto-grants-1988_05
- 특허 번호
- US04742063
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