Hydrochloric Acid → HCID 14209243, 화합물

HRID 1252407노트

반응식

HRID 1252407 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH2:13][CH2:14][C:15]1([OH:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.Cl.C(OC(O)C)C>C(N(CC)CC)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:13][CH2:14][C:15]1([OH:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 776141-(Aminomethyl)cyclohexan-1-olHCID 6183063-Bromo-4-chloroquinolineHCID 101298981-Ethoxyethanol

생성물 1

HCID 14209243HCID 14209243, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 3-bromo-4-chloroquinoline (12.1 g), 1-aminomethyl-1-cyclohexanol.HCl (8.3 g), triethylamine (7.2 g) and 30 ml of ethoxyethanol was stirred at 120° C. for 5 hours and poured into 250 ml of ice water. The solid was filtered and recrystallized from acetone. The yield was 6.5 g, mp 130°-132° C.

후처리

  1. filtrationThe solid was filtered
  2. customrecrystallized from acetone

출처 및 근거

ORD 기록
ord-1fbd96ddb7a14805b786857e3cbf755b
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743601

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