Acetic Anhydride → N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide

반응식

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)[N:6]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=2)[N:6]=1)(=[O:18])[CH3:17]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 164202-Amino-4-(p-nitrophenyl)thiazole

생성물 1

HCID 745427N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide

실험 절차

30 g of 2-amino-4-(4'-nitrophenyl)-1,3-thiazole (prepared in accordance with J. Chem. Soc. 1059, (2365) and 100 ml of acetic anhydride are heated for 3 hours at 140° C. Excess acetic anhydride is removed by vacuum distillation and the residue is treated with 500 ml of warm water, filtered, washed, and dried to constant weight, affording 34 g of 2-acetamido-4-(4'-nitrophenyl)-1,3-thiazole.

후처리

customExcess acetic anhydride is removed by vacuum distillation
additionthe residue is treated with 500 ml of warm water
filtrationfiltered
washwashed
customdried to constant weight

출처 및 근거

ORD 기록: ord-aa8da901ce8146c492e4f0ec031eed6b
출처 데이터셋: uspto-grants-1988_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04743683

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