Hydrochloric Acid → 3-(Acetylthio)-2-[(acetylthio)methyl]propanoic acid

HRID 1252826

반응식

HRID 1252826 반응식
[C:1]([OH:4])(=[S:3])[CH3:2].Br[CH2:6][CH:7]([CH2:11]Br)[C:8]([OH:10])=[O:9].Cl>[OH-].[K+]>[C:1]([S:3][CH2:6][CH:7]([CH2:11][S:3][C:1](=[O:4])[CH3:2])[C:8]([OH:10])=[O:9])(=[O:4])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3189153-Bromo-2-(bromomethyl)propionic acidHCID 178418634HCID 178418634, 화합물

생성물 1

HCID 131455313-(Acetylthio)-2-[(acetylthio)methyl]propanoic acid

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

A solution of 3.36 g (40 mmoles) of thioacetic acid in 40 ml of N-potassium hydroxide is added dropwise to a solution of 2-bromomethyl-3-bromopropanoic acid in 1.0N potassium hydroxide (20 ml). The mixture is stirred at room temperature overnight, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated in vacuo. The residue is converted into a dicyclohexylammonium salt (m.p. 116°-118°) and the salt converted back into the free acid, 2-(acetylthiomethyl)-3-(acetylthio)propanoic acid, by distribution between ethyl acetate and 10% potassium bisulfate.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic layer is dried
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f0094c45a9b94187bcd71483166700ed
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04745124

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