1-[3-Mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-proline → HCID 53645761, 화합물
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[SH:1][CH2:2][CH:3]([CH2:14][C:15]([O:17]C)=[O:16])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].[H][H]>CO.[OH-].[Na+]>[C:15]([CH2:14][CH:3]([CH2:2][SH:1])[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5])([OH:17])=[O:16]참가 물질
5
실험 절차
To a solution of the product from Example 62, Step (d) (3.0 g) in methanol (60 ml), 1N sodium hydroxide (60 ml) is added. After 4 hours, the solution is applied to a column of Dowex 50 ion exchange resin in the hydrogen cycle, and the desired material is eluted with water to yield 2.3 g of the named product, Rf =0.2 (silica gel-benzene:acetic acid, 75:25).
후처리
- washthe desired material is eluted with water
출처 및 근거
- ORD 기록
- ord-1376bf65a11241a09961188ac94a9f88
- 출처 데이터셋
- uspto-grants-1988_05
- 특허 번호
- US04745124
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