Sodium Hydroxide → HCID 20130662, 화합물

HRID 1252940노트

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HRID 1252940 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:22](=[O:23])[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[N:15]([CH3:24])[C:14]2=[O:25])=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:22](=[O:23])[C:21]3[CH2:20][CH2:19][CH2:18][CH2:17][C:16]=3[N:15]([CH3:24])[C:14]2=[O:25])=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 20130686ethyl 2-chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl]-benzoate

생성물 1

HCID 20130662HCID 20130662, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 3.6 g of ethyl 2-chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3-(2H)-quinazolinyl]-benzoate in 70 ml of ethanol is held at 60° C. for 10 minutes with 0.6 g of sodium hydroxide in 70 ml of water and subsequently stirred for 1 hour. The solution is substantially evaporated down under reduced pressure and the residue is brought to pH 1 with 2N hydrochloric acid. The precipitate is shaken five times with 50 ml amounts of diethyl ether and the organic phases are dried over anhydrous sodium sulphate and evaporated to dryness under reduced pressure. 2-Chloro-5-[1,4,5,6,7,8-hexahydro-1-methyl-2,4-dioxo-3-(2H)-quinazolinyl]-benzoic acid is obtained.

후처리

  1. customThe solution is substantially evaporated down under reduced pressure
  2. stirringThe precipitate is shaken five times with 50 ml amounts of diethyl ether
  3. dry with materialthe organic phases are dried over anhydrous sodium sulphate
  4. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-b29dbd605cd14ddabfb1064976227c6c
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04746352

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