Carbon Tetrachloride → 1-(p-Chlorophenoxy)-3,3-dimethyl-4-chloro-2-butanone

HRID 1253038

반응식

HRID 1253038 반응식
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8](=[O:14])[C:9]([CH3:13])([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Cl)(Cl)(Cl)[Cl:37]>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8](=[O:14])[C:9]([CH3:13])([CH3:12])[CH2:10][Cl:37])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 201382891-(p-Chlorophenoxy)-3,3-dimethyl-4-hydroxy-2-butanone

생성물 1

HCID 201382951-(p-Chlorophenoxy)-3,3-dimethyl-4-chloro-2-butanone

실험 절차

Into a 100-ml egg plant type flask were placed 2.4 g of 1-(p-chlorophenoxy)-3,3-dimethyl-4-hydroxy-2-butanone, 2.6 g of triphenylphosphine and 50 ml of carbon tetrachloride, which were then refluxed for 18 hours. The reaction mixture was cooled, the crystals separating out were filtered off, and the filtrate was concentrated in a vacuum. The residue obtained was purified by silica gel column chromatography, giving 1.8 g of the above-identified desired compound.

후처리

  1. customInto a 100-ml egg plant type flask were placed
  2. temperatureThe reaction mixture was cooled
  3. customthe crystals separating out
  4. filtrationwere filtered off
  5. concentrationthe filtrate was concentrated in a vacuum
  6. customThe residue obtained
  7. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-f8e4ddd6dd9644e38fd966178d844820
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04746673

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