Formic Acid → 1-Chloro-3,3,4-trimethylpentan-2-one

HRID 1253128노트

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HRID 1253128 반응식
[Cl:1][CH:2]=[C:3]([O:10]C1C=CC=CC=1)[C:4]([CH3:9])([CH3:8])[CH:5]([CH3:7])[CH3:6].C(O)=O.Cl>C(Cl)Cl>[Cl:1][CH2:2][C:3](=[O:10])[C:4]([CH3:9])([CH3:8])[CH:5]([CH3:7])[CH3:6]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 54514707[(1-Chloro-3,3,4-trimethylpent-1-en-2-yl)oxy]benzene

생성물 1

HCID 132952261-Chloro-3,3,4-trimethylpentan-2-one수율 77%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

238 g (1 mol) of 1-chloro-2-phenoxy-3,3,4-trimethyl-pent-1-ene are stirred with 500 g of formic acid and 50 g of concentrated hydrochloric acid for 2 hours at 80° C. The mixture is diluted with methylene chloride, and is washed once with water and four times with dilute sodium hydroxide solution. After the mixture has been dried over sodium sulphate, the solvent is stripped off in vacuo, and the residue is distilled over a column. 125 to 135 g (77-83% of theory) of 1-chloro-3,3,4-trimethyl-pentan-2-one of boiling point 88°-93° C./16 mbar are obtained. ##STR17##

후처리

  1. washis washed once with water and four times with dilute sodium hydroxide solution
  2. dry with materialAfter the mixture has been dried over sodium sulphate
  3. distillationthe residue is distilled over a column

출처 및 근거

ORD 기록
ord-d9f745b993ab404499128767c593ba12
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04747869

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