Acetic Anhydride → 2-Methyl-[1,3]thiazolo[4,5-c]pyridine

HRID 1253220노트

반응식

HRID 1253220 반응식
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[SH:10])([O-])=O.[C:11](OC(=O)C)(=O)[CH3:12]>C(O)(=O)C.[Zn]>[CH3:11][C:12]1[S:10][C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:1]=1

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 178526807HCID 178526807, 화합물

생성물 1

HCID 6407212-Methyl-[1,3]thiazolo[4,5-c]pyridine수율 44.5%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

A mixture of 1.3 g of 3-nitropyridine-4-thiol in 4 ml of acetic acid and 15 ml of acetic anhydride containing 1.5 g of zinc dust was heated at reflux for four hours. The reaction mixture was cooled and concentrated to an oil. The oil was dissolved in 5N sodium hydroxide and the alkaline solution was extracted with diethyl ether. The extracts were combined, dried and concentrated to dryness to afford 557 mg of 2-methylthiazolo[4,5-c]pyridine. M+Theory 150; Found 150.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for four hours
  3. temperatureThe reaction mixture was cooled
  4. concentrationconcentrated to an oil
  5. dissolutionThe oil was dissolved in 5N sodium hydroxide
  6. extractionthe alkaline solution was extracted with diethyl ether
  7. customdried
  8. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-b2b877af11624f7986d13499d71bdd0c
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04748172

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