Phosphorus oxybromide → 4-Bromo-1,5-naphthyridine

HRID 1253510노트

반응식

HRID 1253510 반응식
[N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4](O)=[CH:3][CH:2]=1.P(Br)(Br)([Br:14])=O>>[Br:14][C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[N:1]=[CH:2][CH:3]=1

참가 물질

3

반응물 2

HCID 24613Phosphorus oxybromideHCID 178516432HCID 178516432, 화합물

생성물 1

HCID 150257374-Bromo-1,5-naphthyridine

반응 조건

온도
150 °C

실험 절차

A flask was charged with 1,5-naphthyridin-4-ol (1 g, 6.7 mmol) and phosphorousoxybromide (5 g, 17 mmol). The mixture was heated to 150° C., stirred for 1 hour, and then cooled to room temperature. The mixture was poured into ice-water and extracted with toluene. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to give crude product, which was re-crystallized from petroleum ether to give 4-bromo-1,5-naphthyridine.

후처리

  1. temperaturecooled to room temperature
  2. extractionextracted with toluene
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give crude product, which
  8. customwas re-crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-221d1e0d305a498c93b370d8baa12e97
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455477B2

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