m-Chloroperbenzoic acid → HCID 67314368, 화합물

HRID 1254083노트

반응식

HRID 1254083 반응식
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770, 화합물

생성물 1

HCID 67314368HCID 67314368, 화합물수율 73.9%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6344Dichloromethane용매

실험 절차

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

후처리

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

출처 및 근거

ORD 기록
ord-c69c06a9357844abb74d7c552645d600
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455535B2

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