Hydrochloric Acid → 1,3-Dihydro-3-(1(3H)-isobenzofuranylidene)-2H-pyrrolo[3,2-b]pyridin-2-one

HRID 1254153노트

반응식

HRID 1254153 반응식
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.C1COCC1.[C:26]1([C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][O:28]1)=O.Cl.C([O-])(O)=O.[Na+]>CN(C)C=O.O>[C:26]1(=[C:3]2[C:4]3=[N:5][CH:6]=[CH:7][CH:8]=[C:9]3[NH:1][C:2]2=[O:10])[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][O:28]1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 6885PhthalideHCID 3163671,3-Dihydro-2H-pyrrolo[3,2-b]pyridin-2-oneHCID 516892Sodium BicarbonateHCID 23714775LiHMDS tetrahydrofuran

생성물 1

HCID 673143861,3-Dihydro-3-(1(3H)-isobenzofuranylidene)-2H-pyrrolo[3,2-b]pyridin-2-one수율 16%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one (50 mg, 0.37 mmol) in anhydrous N,N-dimethylformamide (5.0 ml) was added 1.0M LiHMDS/THF solution (0.74 ml, 0.74 mmol) under N2. After the mixture was stirred at room temperature for 10 minutes, phthalide was added (40 mg, 0.30 mmol), and then it was continuously stirred at room temperature for 4 hours. The mixture was poured into 2M HCl (4.0 ml), heated at 50° C. for 20 minutes and then poured into water (100 ml). After cooled to room temperature, the mixture was basified to pH 9 with saturated NaHCO3 solution, and was stirred at room temperature overnight. The resulting solid was filtered, washed with water, dried under vacuum and triturated with chloroform to give 3-(3H-isobenzofuran-1-ylidene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one as a yellow solid (12 mg, 16%).

후처리

  1. stirringit was continuously stirred at room temperature for 4 hours
  2. temperatureheated at 50° C. for 20 minutes
  3. temperatureAfter cooled to room temperature
  4. stirringwas stirred at room temperature overnight
  5. filtrationThe resulting solid was filtered
  6. washwashed with water
  7. customdried under vacuum
  8. customtriturated with chloroform

출처 및 근거

ORD 기록
ord-707e0ab750c64f889877bdb650cde649
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455535B2

반응 노트

불러오는 중…