(R)-tert-butyl 3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)piperidine-1-carboxylate → (R)-3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)-piperidine

HRID 1254300노트

반응식

HRID 1254300 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)([O:15][CH3:16])[CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:5]=[CH:6][CH:7]=1>CC#N.Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C@:8]([C@@H:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)([O:15][CH3:16])[CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 67192256(R)-tert-butyl 3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)piperidine-1-carboxylate

생성물 1

HCID 59382902(R)-3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)-piperidine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6342Acetonitrile용매

실험 절차

A quarter of the (R)-tert-butyl 3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)piperidine-1-carboxylate obtained in Step 1 (ca. 75 mg, ca. 0.1 mmol) was dissolved in CH3CN (30 mL) and 2 N HCl (25 mL). The mixture was vigorously stirred at rt for 2 d. The solvents were removed in vacuo to give the HCl salt of (R)-3-((S)-1-(3-chlorophenyl)-1,5-dimethoxypentyl)-piperidine, which was used without further purification. LC-MS (3 min) tR=1.22 min, m/z 328, 326 (M+H+).

후처리

  1. customThe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-ea0d6bfc9c7f4c32bd0656a84a20ab0a
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455521B2

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