3-Aminopropylphosphonic acid → (3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid

HRID 12548

반응식

HRID 12548 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([CH:21]=O)=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[NH2:25][CH2:26][CH2:27][CH2:28][P:29](=[O:32])([OH:31])[OH:30].[BH3-]C#N.[Na+]>CO>[C:15]1([C:14]2[N:13]=[C:12]([CH2:21][NH:25][CH2:26][CH2:27][CH2:28][P:29](=[O:30])([OH:32])[OH:31])[CH:11]=[CH:10][C:9]=2[C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:24])([F:23])[F:1])=[CH:4][CH:5]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 975873-Aminopropylphosphonic acidHCID 5003444Sodium cyanoborohydrideHCID 866190715-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde2회

생성물 1

HCID 59504176(3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Following General Procedure M, 5-(4-trifluoromethylphenyl)-6-phenyl-pyridine-2-carbaldehyde (Compound 57, 58 mg, 0.18 mmol), (3-amino-propyl)-phosphonic acid (25 mg, 0.18 mmol), Bu4NOH (0.18 ml, 0.18 mmol, 1 M in MeOH) and NaCNBH3 (11 mg, 0.18 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-6c223868fa6e418e812f48b461d0ad88
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

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