Phosphorus tribromide → 3-Fluoro-4-(methylsulphonyl)benzyl bromide

HRID 1254900

반응식

HRID 1254900 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:12]O)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].P(Br)(Br)[Br:15]>C(OCC)C.O>[Br:15][CH2:12][C:4]1[CH:5]=[CH:6][C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[C:2]([F:1])[CH:3]=1

참가 물질

5

반응물 2

HCID 24614Phosphorus tribromideHCID 672190853-Fluoro-4-(methylsulphonyl)benzyl alcohol

생성물 1

HCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

To a stirred suspension of (3-fluoro-4-methanesulfonyl-phenyl)-methanol (0.269 g, 1.31 mmol) in diethyl ether (5 ml) under an inert atmosphere of Argon is added dropwise phosphorus tribromide (46 μl, 0.434 mmol). After stirring at room temperature overnight, the reaction mixture is diluted with water (2 ml) and the diethyl ether layer separated. This organic portion is placed over NaOH pellets and after 20 minutes, is used as a reagent in solution in diethyl ether.

후처리

  1. customthe diethyl ether layer separated
  2. waitThis organic portion is placed over NaOH pellets and after 20 minutes

출처 및 근거

ORD 기록
ord-ef5ace8d54f3449a913d26916b6f86c6
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455645B2

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