Aniline → HCID 54889983, 화합물

HRID 1255091노트

반응식

HRID 1255091 반응식
[CH3:1][O:2][C:3](=[O:13])[CH:4](Br)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(C(C)C)C(C)C)C>C(#N)C>[CH3:1][O:2][C:3](=[O:13])[CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 6115AnilineHCID 81531DiisopropylethylamineHCID 18004644Methyl 2-bromo-2-(2-fluorophenyl)acetate

생성물 1

HCID 54889983HCID 54889983, 화합물수율 99.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of bromo-(2-fluoro-phenyl)-acetic acid methyl ester (I259) (1.47 g, 5.95 mmol), aniline (814 ul, 8.93 mmol) and N-ethyl-N-isopropylpropan-2-amine (1.53 mL, 8.93 mmol) in acetonitrile (10 mL) is heated under microwave irradiation at 100° C. for 1 hour. The solvent is evaporated, the residue is taken up with DCM and washed with water and brine, dried over Na2SO4 and evaporated to afford intermediate I262 as a dark brown oil (1.54 g, quantitative yield).

후처리

  1. customThe solvent is evaporated
  2. washwashed with water and brine
  3. dry with materialdried over Na2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-e6d5324d35014fa884d1fd8c0592bb90
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455646B2

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