Ethyl 1-(6-{2-[(4-methoxyphenyl)ethynyl]phenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate → Ethyl 1-(6-{2-[2-(4-methoxyphenyl)ethyl]phenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

HRID 1255209노트

반응식

HRID 1255209 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]2[N:22]=[C:21]([N:23]3[C:27]([C:28]([F:31])([F:30])[F:29])=[C:26]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH:25]=[N:24]3)[CH:20]=[CH:19][CH:18]=2)=[CH:5][CH:4]=1.[H][H]>CCOC(C)=O.CCO.[Pt](=O)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]2[N:22]=[C:21]([N:23]3[C:27]([C:28]([F:31])([F:29])[F:30])=[C:26]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH:25]=[N:24]3)[CH:20]=[CH:19][CH:18]=2)=[CH:5][CH:4]=1

참가 물질

6

반응물 2

HCID 67158916Ethyl 1-(6-{2-[(4-methoxyphenyl)ethynyl]phenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67159519Ethyl 1-(6-{2-[2-(4-methoxyphenyl)ethyl]phenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a degassed solution of the title compound from Example 236 Step A (255 mg, 0.519 mmol) in EtOAc (3 mL) and EtOH (3 mL) was added platinum(IV) oxide (175 mg). The reaction mixture was fitted with a hydrogen balloon attached to a 3-way adapter. The reaction flask was then evacuated and back-filled with hydrogen. After this process was repeated three times, the reaction mixture was placed under a hydrogen atmosphere, and was stirred vigorously. After 2 h, the reaction mixture was filtered through Celite, rinsing with EtOAc. The mixture was then concentrated in vacuo, and used without further purification: LCMS m/z 496.2 [M+H]+.

후처리

  1. customattached to a 3-way adapter
  2. customThe reaction flask was then evacuated
  3. additionback-filled with hydrogen
  4. filtrationthe reaction mixture was filtered through Celite
  5. washrinsing with EtOAc
  6. concentrationThe mixture was then concentrated in vacuo
  7. customused without further purification

출처 및 근거

ORD 기록
ord-07c6d2b3e7574c7bb0f0657072d63a3c
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455638B2

반응 노트

불러오는 중…