Hydrochloric Acid → 2-(4-(2-Hydroxyethyl)phenoxy)acetaldehyde

HRID 1255251노트

반응식

HRID 1255251 반응식
Cl.C([O:4][CH:5](OCC)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=1)C>O1CCOCC1.O>[OH:16][CH2:15][CH2:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][CH2:6][CH:5]=[O:4])=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 579889402-(4-(2,2-Diethoxyethoxy)phenyl)ethanol

생성물 1

HCID 545162782-(4-(2-Hydroxyethyl)phenoxy)acetaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)phenyl)ethanol [Aromatic Intermediate 12, step a] (0.76 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The reaction was diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organic solutions were washed with water (50 mL) and brine (50 mL), then dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound, which was used directly. Yield 0.35 g.

후처리

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. washThe combined organic solutions were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e6e4981aa52041dfa78af14efb0aa268
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455483B2

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