Dichloromethane → N-(2-Sulfanylethyl)pentanamide

HRID 1255371노트

반응식

HRID 1255371 반응식
Cl.[SH:2][CH2:3][CH2:4][NH2:5].C(=O)([O-])[O-].[K+].[K+].[C:12](Cl)(=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16].ClCCl>O>[SH:2][CH2:3][CH2:4][NH:5][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 9082Cysteamine HydrochlorideHCID 11430Potassium CarbonateHCID 61186Valeryl chloride

생성물 1

HCID 22222175N-(2-Sulfanylethyl)pentanamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

Under a nitrogen atmosphere, 22.7 g of 2-mercaptoethylamine hydrochloride (0.2 mol) and 44.3 g of potassium carbonate (0.32 mol) were introduced at room temperature in solution in 130 ml of water. The solution was warmed to 40° C. and 12.0 g of valeryl chloride (0.1 mol) were added dropwise over the course of 15 minutes. The batch was stirred at 40° C. for 3 hours and then cooled to room temperature. 70 ml of dichloromethane were added and a phase separation was carried out. The organic phase was washed with 50 ml of 20% strength ammonium chloride solution, dried over sodium sulfate and freed of its solvent under reduced pressure.

후처리

  1. temperaturecooled to room temperature
  2. customa phase separation
  3. washThe organic phase was washed with 50 ml of 20% strength ammonium chloride solution
  4. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-f51eeac01e55452eae8f120abb552573
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08460445B2

반응 노트

불러오는 중…