Hydrazine hydrate (1:1) → HCID 178514446, 화합물

HRID 1255452노트

반응식

HRID 1255452 반응식
C([O:3][C:4]([C@H:6]1[CH2:11][CH2:10][C@H:9]([OH:12])[CH2:8][CH2:7]1)=O)C.O.[NH2:14][NH2:15]>>[OH:12][C@H:9]1[CH2:10][CH2:11][C@H:6]([C:4]([NH:14][NH2:15])=[O:3])[CH2:7][CH2:8]1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 178472487HCID 178472487, 화합물

생성물 1

HCID 178514446HCID 178514446, 화합물수율 91%

실험 절차

A mixture of cis/trans-4-hydroxycyclohexane carboxylic acid ethyl ester (5.0 g, 29 mmol) and hydrazine hydrate (1.4 g, 29 mmol) was heated at reflux for 24 h. Residual water was removed by azeotropic distillation with toluene. The residue was triturated from tert-butyl methyl ether. The precipitate was collected by filtration and dried in vacuo to give the title compound as white solid in 91% yield.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 24 h
  3. customResidual water was removed by azeotropic distillation with toluene
  4. customThe residue was triturated from tert-butyl methyl ether
  5. filtrationThe precipitate was collected by filtration
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-2fa5d87c486649419bd1b8d562d726e2
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461151B2

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