Ethanol → 6-Bromopyrazolo[1,5-a]pyrimidine

HRID 1255861노트

반응식

HRID 1255861 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[Br:7]/[C:8](=[CH:11]\N(C)C)/[CH:9]=O.C(O)C>C(O)(=O)C>[Br:7][C:8]1[CH:9]=[N:1][C:2]2[N:3]([N:4]=[CH:5][CH:6]=2)[CH:11]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 215914792-Bromo-3-(dimethylamino)acroleinHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 222367016-Bromopyrazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Aminopyrazole (0.75 g, 9.04 mmol) was mixed with (2Z)-2-bromo-3-(dimethylamino)acrylaldehyde obtained at the previous step (1.85 g, 10.4 mmol). Absolute ethanol (20 mL) and glacial acetic acid (2 mL) were added. The reaction mixture was stirred under reflux for 16 h and evaporated to dryness. The residue was washed on a filter with cold ethanol/hexane mixture (3:1) and dried in a vacuum oven at 30° C. to give 6-bromopyrazolo[1,5-a]pyrimidine.

후처리

  1. customobtained at the previous step (1.85 g, 10.4 mmol)
  2. temperatureunder reflux for 16 h
  3. customevaporated to dryness
  4. washThe residue was washed on
  5. filtrationa filter with cold ethanol/hexane mixture (3:1)
  6. customdried in a vacuum oven at 30° C.

출처 및 근거

ORD 기록
ord-8193ef84867742bfaacde2bfec964037
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461162B2

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